An efficient way to increase the binding capability of microcantilever biosensors is here demonstrated by growing zinc oxide nanowires (ZnO NWs) on their active surface. A comprehensive evaluation of the chemical compatibility of ZnO NWs brought to the definition of an innovative functionalization method able to guarantee the proper immobilization of biomolecules on the nanostructured surface. A noteworthy higher amount of grafted molecules was evidenced with colorimetric assays on ZnO NWs-coated devices, in comparison with functionalized and activated silicon flat samples. ZnO NWs grown on silicon microcantilever arrays and activated with the proposed immobilization strategy enhanced the sensor binding capability (and thus the dynamic range) of nearly 1 order of magnitude, with respect to the commonly employed flat functionalized silicon devices.

Functionalized ZnO nanowires for microcantilever biosensors with enhanced binding capability / Stassi, Stefano; Chiado', Alessandro; Cauda, VALENTINA ALICE; Palmara, Gianluca; Canavese, Giancarlo; Laurenti, Marco; Ricciardi, Carlo. - In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. - ISSN 1618-2642. - ELETTRONICO. - 409:10(2017), pp. 2615-2625. [10.1007/s00216-017-0204-2]

Functionalized ZnO nanowires for microcantilever biosensors with enhanced binding capability

STASSI, STEFANO;CHIADO', ALESSANDRO;CAUDA, VALENTINA ALICE;PALMARA, GIANLUCA;CANAVESE, GIANCARLO;LAURENTI, MARCO;RICCIARDI, Carlo
2017

Abstract

An efficient way to increase the binding capability of microcantilever biosensors is here demonstrated by growing zinc oxide nanowires (ZnO NWs) on their active surface. A comprehensive evaluation of the chemical compatibility of ZnO NWs brought to the definition of an innovative functionalization method able to guarantee the proper immobilization of biomolecules on the nanostructured surface. A noteworthy higher amount of grafted molecules was evidenced with colorimetric assays on ZnO NWs-coated devices, in comparison with functionalized and activated silicon flat samples. ZnO NWs grown on silicon microcantilever arrays and activated with the proposed immobilization strategy enhanced the sensor binding capability (and thus the dynamic range) of nearly 1 order of magnitude, with respect to the commonly employed flat functionalized silicon devices.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2672920
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