Porous 3-D scaffolds are proposed as an alternative to the use of bone grafting technique in the situations of not-sufficient spontaneous bone regeneration. In this work, resorbable phosphate fibres and bioactive mesoporous particles (i.e. specific surface area up to 800 m2/g, adjustable pore size between 2 and 50 nm, large pore volume [1]) with different morphology and size were selected to combine the resorption property of the fibres with bioactive property of the powders. TiO2-containing phosphate glass (TiPS2.5) fibres (diameter of 110 m) were fabricated following the preform drawing technique, using a drawing tower, as described elsewhere [2]. A dense silica-based bioactive glass (CEL2) [3] was produced by melt quenching as reference sample. Spherical micro-sized mesoporous glass particles based on SiO2-CaO system (SD_MBG) were produced combining sol-gel method with the aerosol-assisted spray-drying technique [4]. Cu-containing (85SiO2-13CaO-2CuO, % mol, referred as Cu_BGn2%) mesoporous glass nanoparticles, with antibacterial properties, were synthetized by an ultra-sound assisted sol-gel method. To produce the fibrous scaffolds, the selected powder and phosphate glass fibres cut at precise length were placed in a beaker containing 2 ml of ethanol. After ethanol evaporation, the powder/fibre mixture was then randomly placed inside a zirconia cylindrical mould. After the thermal treatment, scaffolds were analyzed with micro-CT in order to investigate their inner structure. By soaking them in SBF, their ability to form hydroxyapatite was investigated. Scaffolds morphology before and after immersion in SBF was studied by FESEM.

Incorporation of mesoporous glass particles in a resorbable glass fibrous scaffolds: a strategy to improve its bioactivity / Bari, Alessandra; Boetti, NADIA GIOVANNA; Novajra, Giorgia; Lousteau, Joris; Fiorilli, SONIA LUCIA; Milanese, Daniel; VITALE BROVARONE, Chiara. - ELETTRONICO. - (2016). (Intervento presentato al convegno Biomah tenutosi a Roma (Italy) nel 17 Ottobre 2016).

Incorporation of mesoporous glass particles in a resorbable glass fibrous scaffolds: a strategy to improve its bioactivity

BARI, ALESSANDRA;BOETTI, NADIA GIOVANNA;NOVAJRA, GIORGIA;LOUSTEAU, JORIS;FIORILLI, SONIA LUCIA;MILANESE, DANIEL;VITALE BROVARONE, CHIARA
2016

Abstract

Porous 3-D scaffolds are proposed as an alternative to the use of bone grafting technique in the situations of not-sufficient spontaneous bone regeneration. In this work, resorbable phosphate fibres and bioactive mesoporous particles (i.e. specific surface area up to 800 m2/g, adjustable pore size between 2 and 50 nm, large pore volume [1]) with different morphology and size were selected to combine the resorption property of the fibres with bioactive property of the powders. TiO2-containing phosphate glass (TiPS2.5) fibres (diameter of 110 m) were fabricated following the preform drawing technique, using a drawing tower, as described elsewhere [2]. A dense silica-based bioactive glass (CEL2) [3] was produced by melt quenching as reference sample. Spherical micro-sized mesoporous glass particles based on SiO2-CaO system (SD_MBG) were produced combining sol-gel method with the aerosol-assisted spray-drying technique [4]. Cu-containing (85SiO2-13CaO-2CuO, % mol, referred as Cu_BGn2%) mesoporous glass nanoparticles, with antibacterial properties, were synthetized by an ultra-sound assisted sol-gel method. To produce the fibrous scaffolds, the selected powder and phosphate glass fibres cut at precise length were placed in a beaker containing 2 ml of ethanol. After ethanol evaporation, the powder/fibre mixture was then randomly placed inside a zirconia cylindrical mould. After the thermal treatment, scaffolds were analyzed with micro-CT in order to investigate their inner structure. By soaking them in SBF, their ability to form hydroxyapatite was investigated. Scaffolds morphology before and after immersion in SBF was studied by FESEM.
2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2656477
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