In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation / Ciofani, Gianni; Danti, Serena; D'Alessandro, Delfo; Ricotti, Leonardo; Moscato, Stefania; Bertoni, Giovanni; Falqui, Andrea; Berrettini, Stefano; Petrini, Mario; Mattoli, Virgilio; Menciassi, Arianna. - In: ACS NANO. - ISSN 1936-0851. - 4:10(2010), pp. 6267-6277. [10.1021/nn101985a]

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

CIOFANI, GIANNI;
2010

Abstract

In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.
2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2621447
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