Archivio Istituzionale della RicercaInert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer fromweak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating onPTFE films through an adhesive layer of self-polymerized 3,4-dihydroxy-DL-phenylalanine(polyDOPA) was developed to improve surface properties. Physico-chemical and morpho-logical analysis demonstra ted the deposition of polyDOPA and HAp, with an increase insurface roughness and wettability. A discontinuous coating was present after 14 days in PBS and MC3T3-E1 cells proliferation and adhesion were improved. Results confirmed thepotential application of polyDOPA/HAp-coated filmsfor periodontal disease treatments.
PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapmenton Polytetrafluoroethylene Surface forApplication in Periodontal Diseases / Nardo, Tiziana; Chiono, Valeria; Ciardelli, Gianluca; Tabrizian, Maryam. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5195. - 16:(2016), pp. 288-298. [10.1002/mabi.201500241]
PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapmenton Polytetrafluoroethylene Surface forApplication in Periodontal Diseases
NARDO, TIZIANA;CHIONO, VALERIA;CIARDELLI, GIANLUCA;
2016
Abstract
Inert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer fromweak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating onPTFE films through an adhesive layer of self-polymerized 3,4-dihydroxy-DL-phenylalanine(polyDOPA) was developed to improve surface properties. Physico-chemical and morpho-logical analysis demonstra ted the deposition of polyDOPA and HAp, with an increase insurface roughness and wettability. A discontinuous coating was present after 14 days in PBS and MC3T3-E1 cells proliferation and adhesion were improved. Results confirmed thepotential application of polyDOPA/HAp-coated filmsfor periodontal disease treatments.
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https://hdl.handle.net/11583/2620067
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