PORTO @ Archivio Istituzionale della Ricerca

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A modeling approach integrated with a novel subject-specific characterization is here proposed for the assessment of hemodynamic values of the arterial tree. A 1D model is adopted to characterize large-to-medium arteries, while the left ventricle, aortic valve and distal micro-circulation sectors are described by lumped submodels. A new velocity profile and a new formulation of the non-linear viscoelastic constitutive relation suitable for the {Q, A} modeling are also proposed. The model is firstly verified semi-quantitatively against literature data. A simple but effective procedure for obtaining subject-specific model characterization from non-invasive measurements is then designed. A detailed subject-specific validation against in vivo measurements from a population of six healthy young men is also performed. Several key quantities of heart dynamics—mean ejected flow, ejection fraction, and left-ventricular end-diastolic, end-systolic and stroke volumes—and the pressure waveforms (at the central, radial, brachial, femoral, and posterior tibial sites) are compared with measured data. Mean errors around 5 and 8%, obtained for the heart and arterial quantities, respectively, testify the effectiveness of the model and its subject-specific characterization.

Modelling and Subject-Specific Validation of the Heart-Arterial Tree System / Guala A.; Camporeale C.; Tosello F.; Canuto C.; Ridolfi L.. - In: ANNALS OF BIOMEDICAL ENGINEERING. - ISSN 0090-6964. - STAMPA. - 43:1(2015), pp. 222-237. [10.1007/s10439-014-1163-9]

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