Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the popu- lation and its medical relevance, is largely investigated in both clinical and bioengineering sciences. However, some important feedback mechanisms are still not clearly estab- lished. The present study aims at understanding the global response of the cardiovascular system during paroxysmal AF through a lumped-parameter approach, which is here performed paying particular attention to the stochastic modeling of the irregular heartbeats and the reduced con- tractility of the heart. AF can be here analyzed by means of a wide number of hemodynamic parameters and avoiding the presence of other pathologies, which usually accom- pany AF. Reduced cardiac output with correlated drop of ejection fraction and decreased amount of energy con- verted to work by the heart during blood pumping, as well as higher left atrial volumes and pressures are some of the most representative results aligned with the existing clini- cal literature and here emerging during acute AF. The pre- sent modeling, providing new insights on cardiovascular variables which are difficult to measure and rarely reported in literature, turns out to be an efficient and powerful tool for a deeper comprehension and prediction of the arrythmia impact on the whole cardiovascular system.

Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach / Scarsoglio, Stefania; Guala, Andrea; Camporeale, CARLO VINCENZO; Ridolfi, Luca. - In: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. - ISSN 0140-0118. - STAMPA. - 52:11(2014), pp. 905-920. [10.1007/s11517-014-1192-4]

Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach

SCARSOGLIO, STEFANIA;GUALA, ANDREA;CAMPOREALE, CARLO VINCENZO;RIDOLFI, LUCA
2014

Abstract

Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the popu- lation and its medical relevance, is largely investigated in both clinical and bioengineering sciences. However, some important feedback mechanisms are still not clearly estab- lished. The present study aims at understanding the global response of the cardiovascular system during paroxysmal AF through a lumped-parameter approach, which is here performed paying particular attention to the stochastic modeling of the irregular heartbeats and the reduced con- tractility of the heart. AF can be here analyzed by means of a wide number of hemodynamic parameters and avoiding the presence of other pathologies, which usually accom- pany AF. Reduced cardiac output with correlated drop of ejection fraction and decreased amount of energy con- verted to work by the heart during blood pumping, as well as higher left atrial volumes and pressures are some of the most representative results aligned with the existing clini- cal literature and here emerging during acute AF. The pre- sent modeling, providing new insights on cardiovascular variables which are difficult to measure and rarely reported in literature, turns out to be an efficient and powerful tool for a deeper comprehension and prediction of the arrythmia impact on the whole cardiovascular system.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2576940
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