Pumping protons across a membrane was a critical step at the origin of life on earth, and it is still performed in all living organisms, including in human cells. Proton pumping is paramount to keep normal cells alive, e.g. for lysosomal digestion and for preparing peptides for immune recognition, but it goes awry in cancer cells. They acidify their microenvironment hence membrane voltage is lowered, which in turn induces cell proliferation, ahallmark of cancer. Protonpumping isachieved by meansof rotary motors,namely vacuolar ATPases(V-ATPase), whicharepresentat manyofthe multiplecellularinterfaces. Therefore,we undertook an examination of the thermodynamic properties of V-ATPases. The principal result is that the V-ATPase-mediated control of the cell membrane potential and the related and consequent environmental pH can potentially represent a valuable support strategy for anticancer therapies. A constructal theory approach is used as a new viewpoint to study how V-ATPase can be modulated for therapeutic purposes. In particular, V-ATPase can be regulated by using external fields, such as electromagnetic fields, and a theoretical approach has been introduced to quantify the appropriate field strength and frequency for this new adjuvant therapeutic strategy.
A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach / Umberto Lucia;Antonio Ponzetto;Thomas S. Deisboeck. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 4:6763(2014), pp. 1-7.
|Titolo:||A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/srep06763|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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