Force traction microscopy is an inversion method that allows us to obtain the stress field applied by a living cell on the environment on the basis of a pointwise knowledge of the displacement produced by the cell itself. This classical biophysical problem, usually addressed in terms of Green’s functions, can be alternatively tackled in a variational framework. In such a case, a variation of the error functional under suitable regularization is operated in view of its minimization. This setting naturally suggests the introduction of a new equation, based on the adjoint operator of the elasticity problem. In this paper, we illustrate a numerical strategy of the inversion method that discretizes the partial differential equations associated with the optimal control problem by finite elements. A detailed discussion of the numerical approximation of a test problem (with known solution) that contains most of the mathematical difficulties of the real one allows a precise evaluation of the degree of confidence that one can achieve in the numerical results.
A numerical method for the inverse problem of cell traction in 3D / G. Vitale; D. Ambrosi; L. Preziosi. - In: INVERSE PROBLEMS. - ISSN 0266-5611. - 28(2012), pp. 095013-1-095013-18. [10.1088/0266-5611/28/9/095013]
|Titolo:||A numerical method for the inverse problem of cell traction in 3D|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1088/0266-5611/28/9/095013|
|Appare nelle tipologie:||1.1 Articolo in rivista|