The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of hydra, the sphere breaks its initial symmetry to form a foot–head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.
Critical behavior and axis defining symmetry breaking in Hydra embryonic development / Gamba, ANDREA ANTONIO; Nicodemi, M.; Soriano, J.; Ott, A.. - In: PHYSICAL REVIEW LETTERS. - ISSN 0031-9007. - STAMPA. - 108:15(2012), pp. 158103-1-158103-5. [10.1103/PhysRevLett.108.158103]
Critical behavior and axis defining symmetry breaking in Hydra embryonic development
GAMBA, ANDREA ANTONIO;
2012
Abstract
The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of hydra, the sphere breaks its initial symmetry to form a foot–head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.Pubblicazioni consigliate
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https://hdl.handle.net/11583/2496030
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