Archivio Istituzionale della RicercaThe preparation and characterization of PCL guides filled with a porous matrix of a freeze-dried, genipin-crosslinked gelatin sponge (GL/GP) is described. Porous guides are obtained by dip coating a rotating mandrel with a PCL/PEO blend solution followed by PEO solvent extraction. PCL/PEO 60/40 is selected as the optimal composition to obtain model porous membranes with suitable morphological properties to ensure nutrient permeation and moderate stiffness. GL/GP sponges show increased mechanical strength and water stability, compared to uncrosslinked GL sponges. GL/GP in the form of films, sponges and internal fillers support the in vitro adhesion and proliferation of Schwann like cells.
Porous poly(ε-caprolactone) nerve guide filled with porous gelatin matrix for nerve tissue engineering / TONDA TURO, Chiara; C., Audisio; S., Gnavi; Chiono, Valeria; Gentile, Piergiorgio; S., Raimondo; S., Geuna; I., Perroteau; Ciardelli, Gianluca. - In: ADVANCED ENGINEERING MATERIALS. - ISSN 1438-1656. - 13:5(2011), pp. B151-B164. [10.1002/adem.201080099]
Porous poly(ε-caprolactone) nerve guide filled with porous gelatin matrix for nerve tissue engineering
TONDA TURO, CHIARA;CHIONO, VALERIA;GENTILE, PIERGIORGIO;CIARDELLI, GIANLUCA
2011
Abstract
The preparation and characterization of PCL guides filled with a porous matrix of a freeze-dried, genipin-crosslinked gelatin sponge (GL/GP) is described. Porous guides are obtained by dip coating a rotating mandrel with a PCL/PEO blend solution followed by PEO solvent extraction. PCL/PEO 60/40 is selected as the optimal composition to obtain model porous membranes with suitable morphological properties to ensure nutrient permeation and moderate stiffness. GL/GP sponges show increased mechanical strength and water stability, compared to uncrosslinked GL sponges. GL/GP in the form of films, sponges and internal fillers support the in vitro adhesion and proliferation of Schwann like cells.
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https://hdl.handle.net/11583/2420739
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