Archivio Istituzionale della RicercaA method for obtaining composite medical materials based on polyvinylpyrrolidone (PVP K15) modified with ketoprofen in a medium of supercritical carbon dioxide and with Ag nanoparticles prepared by metal vapor synthesis is developed. A system in which ketoprofen and Ag nanoparticles with an average size of ~16 nm are uniformly distributed over the bulk of PVP is obtained. It is found that the yield of ketoprofen from the composite in the physiological solution is higher than that for an analogous system obtained by mechanical mixing of the components.
Composite materials for medical purposes basedon polyvinylpyrrolidone modified with ketoprofenand silver nanoparticles / Nikitin, L. N.; Vasil’Kov, A. Y. u.; Banchero, Mauro; Manna, Luigi; Naumkin, A. V.; Podshibikhin, V. L.; Abramchuk, S. S.; Buzin, M. I.; Korlyukov, A. A.; Khokhlov, A. R.. - In: RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY. - ISSN 0036-0244. - STAMPA. - 85:7(2011), pp. 1190-1195. [10.1134/S0036024411070223]
Composite materials for medical purposes basedon polyvinylpyrrolidone modified with ketoprofenand silver nanoparticles
BANCHERO, Mauro;MANNA, LUIGI;
2011
Abstract
A method for obtaining composite medical materials based on polyvinylpyrrolidone (PVP K15) modified with ketoprofen in a medium of supercritical carbon dioxide and with Ag nanoparticles prepared by metal vapor synthesis is developed. A system in which ketoprofen and Ag nanoparticles with an average size of ~16 nm are uniformly distributed over the bulk of PVP is obtained. It is found that the yield of ketoprofen from the composite in the physiological solution is higher than that for an analogous system obtained by mechanical mixing of the components.
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https://hdl.handle.net/11583/2398054
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