Thromboembolism and the attendant risk of cardioembolic stroke remains an impediment to the development of prosthetic cardiovascular devices. In particular, altered haemodynamics are implicated in the acute blood cell damage that leads to thromboembolic complications, with platelet activation being the underlying mechanism for cardioemboli formation in blood flow past mechanical heart valves (MHVs) and other blood re-circulating devices. In this work, a new modeling paradigm for evaluating the cardioembolic risk of MHVs is described. In silico fluid–structure interaction (FSI) approach is used for providing a realistic representation of the flow through a bileaflet MHV model, and a Lagrangian analysis is adopted for characterizing the mechanism of mechanically induced activation of platelets by means of a mathematical model for platelet activation state prediction. Additionally, the relationship between the thromboembolic potency of the device and the local flow dynamics is quantified by giving a measure of the role played by the local streamwise and spanwise vorticity components.

Blood damage safety of prosthetic heart valves. Shear-induced platelet activation and local flow dynamics: A fluid-structure interaction approach / Morbiducci, Umberto; Ponzini, R.; Nobili, M.; Massai, DIANA NADA CATERINA; Montevecchi, Franco Maria; Bluestein, D; Redaelli, A.. - In: JOURNAL OF BIOMECHANICS. - ISSN 0021-9290. - 42:12(2009), pp. 1952-1960. [10.1016/j.jbiomech.2009.05.014]

Blood damage safety of prosthetic heart valves. Shear-induced platelet activation and local flow dynamics: A fluid-structure interaction approach

MORBIDUCCI, UMBERTO;MASSAI, DIANA NADA CATERINA;MONTEVECCHI, Franco Maria;
2009

Abstract

Thromboembolism and the attendant risk of cardioembolic stroke remains an impediment to the development of prosthetic cardiovascular devices. In particular, altered haemodynamics are implicated in the acute blood cell damage that leads to thromboembolic complications, with platelet activation being the underlying mechanism for cardioemboli formation in blood flow past mechanical heart valves (MHVs) and other blood re-circulating devices. In this work, a new modeling paradigm for evaluating the cardioembolic risk of MHVs is described. In silico fluid–structure interaction (FSI) approach is used for providing a realistic representation of the flow through a bileaflet MHV model, and a Lagrangian analysis is adopted for characterizing the mechanism of mechanically induced activation of platelets by means of a mathematical model for platelet activation state prediction. Additionally, the relationship between the thromboembolic potency of the device and the local flow dynamics is quantified by giving a measure of the role played by the local streamwise and spanwise vorticity components.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2302907
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