BACKGROUND: Tissue invasion, one of the hallmarks of cancer, is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value. MODEL AND CONCLUSION: We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical result, i.e. an index that predicts tumor invasion based on a few measurable parameters. We discuss its application in the context of experimental data and suggest potential clinical implications.
Morphological instability and cancer invasion: a "splashing water drop" analogy / P.P. DELSANTO; C. GUIOT; T.S. DEISBOECK. - In: THEORETICAL BIOLOGY AND MEDICAL MODELLING. - ISSN 1742-4682. - 4:4(2007).
|Titolo:||Morphological instability and cancer invasion: a "splashing water drop" analogy|
|Data di pubblicazione:||2007|
|Appare nelle tipologie:||1.1 Articolo in rivista|