Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions between cells and between cells and the fibrous environment. The evolution depends on the fibre distribution, as cells preferentially move along the fibre direction and tend to cleave and remodel the extracellular matrix when their direction of motion is not aligned with the fibre direction. Simulations are performed to describe the behavior of ensemble of cells under the action of a chemotactic field and in presence of heterogeneous and anisotropic fibre networks.

Modeling cell movement in anisotropic and heterogeneous network tissues / A., Chauviere; T., Hillen; Preziosi, Luigi. - In: NETWORKS AND HETEROGENEOUS MEDIA. - ISSN 1556-1801. - 2:(2007), pp. 333-357. [10.3934/nhm.2007.2.333]

Modeling cell movement in anisotropic and heterogeneous network tissues

PREZIOSI, LUIGI
2007

Abstract

Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions between cells and between cells and the fibrous environment. The evolution depends on the fibre distribution, as cells preferentially move along the fibre direction and tend to cleave and remodel the extracellular matrix when their direction of motion is not aligned with the fibre direction. Simulations are performed to describe the behavior of ensemble of cells under the action of a chemotactic field and in presence of heterogeneous and anisotropic fibre networks.
File in questo prodotto:
File Dimensione Formato  
CHP.pdf

accesso aperto

Tipologia: 1. Preprint / submitted version [pre- review]
Licenza: PUBBLICO - Tutti i diritti riservati
Dimensione 2.78 MB
Formato Adobe PDF
2.78 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/1655281
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo