The self-regulatory interactions between cells and the vascular system are mediated by signals propagating at a finite speed. In order to build up a physical model of these processes, several features, such as storing of internal energy, nonclassical nonlinear behavior, and delay and threshold effects, have to be taken into account. Considering cells as particles in different metabolic states according to their internal energy, we have developed a model based on the local interaction simulation approach. Several numerical results, in qualitative agreement with biological observations, illustrate the applicability of the model and the method to implement it.
Local interaction simulation approach for the response of the vascular system to metabolic changes of cell behavior / Scalerandi, Marco; Pescarmona, Gp; Delsanto, PIER PAOLO; CAPOGROSSO SANSONE, Barbara. - In: PHYSICAL REVIEW E, STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS. - ISSN 1539-3755. - 63:1(2001), pp. 11901-11901. [10.1103/PhysRevE.63.011901]
Local interaction simulation approach for the response of the vascular system to metabolic changes of cell behavior
SCALERANDI, MARCO;DELSANTO, PIER PAOLO;CAPOGROSSO SANSONE, Barbara
2001
Abstract
The self-regulatory interactions between cells and the vascular system are mediated by signals propagating at a finite speed. In order to build up a physical model of these processes, several features, such as storing of internal energy, nonclassical nonlinear behavior, and delay and threshold effects, have to be taken into account. Considering cells as particles in different metabolic states according to their internal energy, we have developed a model based on the local interaction simulation approach. Several numerical results, in qualitative agreement with biological observations, illustrate the applicability of the model and the method to implement it.Pubblicazioni consigliate
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https://hdl.handle.net/11583/1399433
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