Nanoassembly ( 1 ) for inducing apoptosis in cancer cells comprising : a core ( 2 ) comprising at least a nanoparticle of a nano structured and semiconductor metal oxide , said nanoparticle being monocrystalline or polycrystalline ; a shell ( 3 ) formed by a double phospholipid layer and proteins derived from an extracellular biovesicole chosen between an exosome , an ectosome , a connectosome , an oncosome and an apoptotic body , and an oncosome , said core ( 2 ) being enclosed inside said shell ( 3 ) ; and a plurality of targeting molecules ( 4 , 4 ' , 4 " ) of said cancer cells , preferably mono clonal antibodies ( 4 , 4 ' , 4 " ) , said molecules ( 4 , 4 , 4 " ) being anchored to the external surface of said biovesicole .

BIOMIMETIC NON - IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY / Cauda, Valentina Alice; Canavese, Giancarlo; Limongi, Tania; Garino, Nadia; Laurenti, Marco; Racca, Luisa; Ancona, Andrea; Canta, Marta; Dumontel, Bianca. - (2020).

BIOMIMETIC NON - IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY

Valentina Alice CAUDA;Giancarlo CANAVESE;Tania LIMONGI;Nadia GARINO;Marco LAURENTI;Luisa RACCA;Andrea ANCONA;Marta CANTA;Bianca DUMONTEL
2020

Abstract

Nanoassembly ( 1 ) for inducing apoptosis in cancer cells comprising : a core ( 2 ) comprising at least a nanoparticle of a nano structured and semiconductor metal oxide , said nanoparticle being monocrystalline or polycrystalline ; a shell ( 3 ) formed by a double phospholipid layer and proteins derived from an extracellular biovesicole chosen between an exosome , an ectosome , a connectosome , an oncosome and an apoptotic body , and an oncosome , said core ( 2 ) being enclosed inside said shell ( 3 ) ; and a plurality of targeting molecules ( 4 , 4 ' , 4 " ) of said cancer cells , preferably mono clonal antibodies ( 4 , 4 ' , 4 " ) , said molecules ( 4 , 4 , 4 " ) being anchored to the external surface of said biovesicole .
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2853368