Computational models for tumor growth provide an effective in silico tool to investigate the different stages of cancer growth. Recently, a series of computational models based on porous media theory has been proposed to predict tumor evolution and its interactions with the host tissue. In addition, a specialization of the original models, adapted for tumor spheroids, has been proposed and validated experimentally. However, due to the complexity of the modeling framework, a systematic understanding of the role of the parameters governing the equations is still lacking. In this work, we perform a parametric analysis on a set of fundamental parameters appearing in the model equations. We investigate the effects of a variation of these coefficients on the spheroid growth curves and, in particular, on the final radii reached by the cell aggregates in the growth saturation stage. Finally, we provide a discussion of the results and give a brief summary of our findings.

A parametric study of a multiphase porous media model for tumor spheroids and environment interactions / Mascheroni, P.; Boso, D. P.; Stigliano, C.; Carfagna, M.; Preziosi, L.; Decuzzi, P.; Schrefler, B. A. - In: ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering[s.l] : National Technical University of Athens, 2016. - ISBN 978-618-82844-0-1. - pp. 178-187 [10.7712/100016.1802.12118]

A parametric study of a multiphase porous media model for tumor spheroids and environment interactions

Carfagna M.;Preziosi L.;Decuzzi P.;
2016

Abstract

Computational models for tumor growth provide an effective in silico tool to investigate the different stages of cancer growth. Recently, a series of computational models based on porous media theory has been proposed to predict tumor evolution and its interactions with the host tissue. In addition, a specialization of the original models, adapted for tumor spheroids, has been proposed and validated experimentally. However, due to the complexity of the modeling framework, a systematic understanding of the role of the parameters governing the equations is still lacking. In this work, we perform a parametric analysis on a set of fundamental parameters appearing in the model equations. We investigate the effects of a variation of these coefficients on the spheroid growth curves and, in particular, on the final radii reached by the cell aggregates in the growth saturation stage. Finally, we provide a discussion of the results and give a brief summary of our findings.
2016
978-618-82844-0-1
ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2831555