Living organisms synthesize functional materials, based on proteins and polysaccharides, using enzyme-catalyzed reactions. According to the biomimetic approach, biomaterial matrices for tissue engineering are designed to be able to mimic the properties and the functions of the extracellular matrix (ECM). In this chapter, the most significant research efforts dedicated to the study and the preparation of biomimetic materials through enzymatic modifications were reviewed. The functionalizations of different polymeric matrices obtained through the catalytic activity of two enzymes (Transglutaminase, TGase and Tyrosinase, TYRase) were discussed. Specifically, the biomimetic applications of TGase and TYRase to confer appropriate biomimetic properties to the biomaterials, such as the possibility to obtain in situ gelling hydrogels and the incorporation of bioactive molecules (growth factors) and cell-binding peptides into the scaffolds, were reviewed.

Biomimetic Materials for Medical Application Through Enzymatic Modification / Gentile, Piergiorgio; Chiono, Valeria; TONDA TURO, Chiara; Sartori, Susanna; Ciardelli, Gianluca - In: Biofunctionalization of Polymers and their Applications[s.l] : Springer, 2011. - ISBN 978-3-642-21948-1. - pp. 181-205 [10.1007/10_2010_85]

Biomimetic Materials for Medical Application Through Enzymatic Modification

GENTILE, PIERGIORGIO;CHIONO, VALERIA;TONDA TURO, CHIARA;SARTORI, SUSANNA;CIARDELLI, GIANLUCA
2011

Abstract

Living organisms synthesize functional materials, based on proteins and polysaccharides, using enzyme-catalyzed reactions. According to the biomimetic approach, biomaterial matrices for tissue engineering are designed to be able to mimic the properties and the functions of the extracellular matrix (ECM). In this chapter, the most significant research efforts dedicated to the study and the preparation of biomimetic materials through enzymatic modifications were reviewed. The functionalizations of different polymeric matrices obtained through the catalytic activity of two enzymes (Transglutaminase, TGase and Tyrosinase, TYRase) were discussed. Specifically, the biomimetic applications of TGase and TYRase to confer appropriate biomimetic properties to the biomaterials, such as the possibility to obtain in situ gelling hydrogels and the incorporation of bioactive molecules (growth factors) and cell-binding peptides into the scaffolds, were reviewed.
978-3-642-21948-1
Biofunctionalization of Polymers and their Applications
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2378763
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