Molecular Dynamics And Binding Mechanisms Of Volatile Anesthetics Targeting Human Tubulin

Anesthesia, despite being the cornerstone of modern surgery, is to this date a biological puzzle. While scientific efforts still have not managed to frame its pharmacology in an exhaustive theoretical framework, microtubules inside neurons are thought to be essential for memory formation and consciousness. The potential ability of volatile anesthetics to alter or dampen the vibrational properties of microtubules justifies the spatiotemporal characterization of the interaction between such molecules and the tubulin dimer through the use of computational molecular modelling.