Archivio Istituzionale della RicercaDifferent bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.
Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica / Schloßbauer, Axel; Sauer, Anna M.; Cauda, VALENTINA ALICE; Schmidt, Alexandra; Engelke, Hanna; Rothbauer, Ulrich; Zolghadr, Kourosh; Leonhardt, Heinrich; Bräuchle, Christoph; Bein, Thomas. - In: ADVANCED HEALTHCARE MATERIALS. - ISSN 2192-2640. - 1:3(2012), pp. 316-320. [10.1002/adhm.201100033]
Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica
CAUDA, VALENTINA ALICE;BEIN, THOMAS
2012
Abstract
Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.
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https://hdl.handle.net/11583/2646104
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