Automated computer-aided detection systems for measurement of the carotid intima-media thickness (IMT) are becoming popular. These systems yield lumen-intima (LI) and media-adventitia (MA) borders. In this work, we developed and validated a novel and patented completely automated IMT measurement system called carotid measurement using dual snakes (CMUDS): a class of AtheroEdge system (Global Biomedical Technologies, Inc, Roseville, CA). CMUDS is modeled as a dual parametric system corresponding to LI and MA borders with initialization from the far adventitia layer. The novelty of CMUDS is the first-order absolute moment–based external energy, which provides stable deformation. The dual snakes evolve simultaneously and are forced to maintain a regularized distance to prevent collapsing or bleeding. Two independent readers manually traced the LI/MA boundaries of a multi-institutional, multiethnic, and multi-scanner database of 665 longitudinal images for performance evaluation. CMUDS was also benchmarked against a previously developed automated technique. CMUDS correctly processed 660 images (99.2% success). The differences between the CMUDS and two manual IMT measurements (mean ± SD) were 0.013 ± 0.216 and –0.021 ± 0.197 mm, respectively. The corresponding figures of merit for CMUDS compared to reader tracings were 98.4% and 97.5%. Compared to the previous technique (IMT differences, 0.022 ± 0.276 and –0.012 ± 0.266 mm), CMUDS improved accuracy (Wilcoxon P < 0.009) and variability (Fisher P < 10–8). Among different resolution images from original equipment manufacturer ultrasound scanners, CMUDS performed best with high-resolution images corresponding to 0.0789 mm/pixel. Accuracy in IMT measurement with the proposed automated CMUDS technique makes this system adaptable to large multi-center studies, in which such an IMT measurement system would be very useful tool.

Fully automated dual-snake formulation for carotid intima-media thickness measurement: a new approach / Molinari, Filippo; Meiburger, KRISTEN MARIKO; Saba, L; Zeng, G; Acharya, Ur; Ledda, M; Nicolaides, A; Suri, Js. - In: JOURNAL OF ULTRASOUND IN MEDICINE. - ISSN 0278-4297. - ELETTRONICO. - 31:7(2012), pp. 1123-1136.

Fully automated dual-snake formulation for carotid intima-media thickness measurement: a new approach.

MOLINARI, FILIPPO;MEIBURGER, KRISTEN MARIKO;
2012

Abstract

Automated computer-aided detection systems for measurement of the carotid intima-media thickness (IMT) are becoming popular. These systems yield lumen-intima (LI) and media-adventitia (MA) borders. In this work, we developed and validated a novel and patented completely automated IMT measurement system called carotid measurement using dual snakes (CMUDS): a class of AtheroEdge system (Global Biomedical Technologies, Inc, Roseville, CA). CMUDS is modeled as a dual parametric system corresponding to LI and MA borders with initialization from the far adventitia layer. The novelty of CMUDS is the first-order absolute moment–based external energy, which provides stable deformation. The dual snakes evolve simultaneously and are forced to maintain a regularized distance to prevent collapsing or bleeding. Two independent readers manually traced the LI/MA boundaries of a multi-institutional, multiethnic, and multi-scanner database of 665 longitudinal images for performance evaluation. CMUDS was also benchmarked against a previously developed automated technique. CMUDS correctly processed 660 images (99.2% success). The differences between the CMUDS and two manual IMT measurements (mean ± SD) were 0.013 ± 0.216 and –0.021 ± 0.197 mm, respectively. The corresponding figures of merit for CMUDS compared to reader tracings were 98.4% and 97.5%. Compared to the previous technique (IMT differences, 0.022 ± 0.276 and –0.012 ± 0.266 mm), CMUDS improved accuracy (Wilcoxon P < 0.009) and variability (Fisher P < 10–8). Among different resolution images from original equipment manufacturer ultrasound scanners, CMUDS performed best with high-resolution images corresponding to 0.0789 mm/pixel. Accuracy in IMT measurement with the proposed automated CMUDS technique makes this system adaptable to large multi-center studies, in which such an IMT measurement system would be very useful tool.
2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2498017
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